March marks the beginning of Kidney Cancer Awareness Month, and today is World Kidney Day. In recognition of these, we are proud to present some of our kidney cancer research that has published within the open access oncology journal portfolio.

Kidney cancer, also referred to as renal cancer, is a global health problem currently ranked the 14th most common cancer worldwide. The prevalence of kidney cancer varies according to geographic location and the U.S. and the UK fall within the Top 20 countries with the highest incidence of kidney cancer in 2018. Kidney cancer incidence also differs according to sex, and the disease is more common in men than women.

As a global health issue, continued research on kidney cancer is of paramount significance with particular reference to risk assessment and diagnostics, precision medicine, therapeutics and epigenetics. The articles in this collection have been curated by our oncology journal Editors and include some of the latest research in the field in each of these categories.

Risk assessment and diagnostics

CT texture analysis: a potential tool for prediction of survival in patients with metastatic clear cell carcinoma treated with sunitinib

CT texture analysis: a potential tool for predicting the Fuhrman grade of clear-cell renal carcinoma

Downregulation of CLDN7 due to promoter hypermethylation is associated with human clear cell renal cell carcinoma progression and poor prognosis

Favorable mortality-to-incidence ratios of kidney Cancer are associated with advanced health care systems

LncRNA HOTAIR regulates HIF-1α/AXL signaling through inhibition of miR-217 in renal cell carcinoma

Lysophosphatidylcholine acyltransferase 1 upregulation and concomitant phospholipid alterations in clear cell renal cell carcinoma

Mono, bi- and tri-exponential diffusion MRI modelling for renal solid masses and comparison with histopathological findings

Promoter methylation inhibits expression of tumor suppressor KIBRA in human clear cell renal cell carcinoma

Renal cell carcinoma with venous extension: prediction of inferior vena cava wall invasion by MRI

TGR5 expression in normal kidney and renal neoplasms

Precision Medicine

Renal cancer: new models and approach for personalizing therapy

Therapeutics

A prospective phase I dose-escalation trial of stereotactic ablative radiotherapy (SABR) as an alternative to cytoreductive nephrectomy for inoperable patients with metastatic renal cell carcinoma

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Combined high dose radiation and pazopanib in metastatic renal cell carcinoma: a phase I dose escalation trial

Cost-effectiveness of nivolumab in patients with advanced renal cell carcinoma treated in the United States

Image-guided minimally invasive treatment for small renal cell carcinoma

Increased risk of everolimus-associated acute kidney injury in cancer patients with impaired kidney function

KAT3B-p300 and H3AcK18/H3AcK14 levels are prognostic markers for kidney ccRCC tumor aggressiveness and target of KAT inhibitor CPTH2

Kidney autotransplantation after nephrectomy and work bench surgery as an ultimate approach to nephron-sparing surgery

Methylation profiling and evaluation of demethylating therapy in renal cell carcinoma

Notch signaling plays a crucial role in cancer stem-like cells maintaining stemness and mediating chemotaxis in renal cell carcinoma

Safety of pazopanib and sunitinib in treatment-naive patients with metastatic renal cell carcinoma: Asian versus non-Asian subgroup analysis of the COMPARZ trial

Single-cell analysis reveals congruence between kidney organoids and human fetal kidney

Targeting 3-phosphoinositide-dependent protein kinase 1 associated with drug-resistant renal cell carcinoma using new oridonin analogs

The role of apoptosis repressor with a CARD domain (ARC) in the therapeutic resistance of renal cell carcinoma (RCC): the crucial role of ARC in the inhibition of extrinsic and intrinsic apoptotic signalling

Tips and tricks for a safe and effective image-guided percutaneous renal tumour ablation

Wilms’ tumor 1-associating protein promotes renal cell carcinoma proliferation by regulating CDK2 mRNA stability


Epigenetics

CBFA2T2 is associated with a cancer stem cell state in renal cell carcinoma

Identification and validation of a 44-gene expression signature for the classification of renal cell carcinomas

Mutated Von Hippel-Lindau-renal cell carcinoma (RCC) promotes patients specific natural killer (NK) cytotoxicity

Somatic mutations in renal cell carcinomas from Chinese patients revealed by whole exome sequencing

TFE3 fusions escape from controlling of mTOR signaling pathway and accumulate in the nucleus promoting genes expression in Xp11.2 translocation renal cell carcinomas


Articles from the following journals have been included in this collection: BMC Cancer, Cancer Imaging, Cancer Cell International, Cell Communication & Signaling, Cell Death & Disease, Clinical Epigenetics, Diagnostic Pathology, Experimental Hematology & Oncology, Genome Medicine, Insights into Imaging, Journal of Experimental & Clinical Cancer Research, Journal of Hematology & Oncology, Radiation Oncology and World Journal of Surgical Oncology.

Now that you have read the research, why not test your knowledge of kidney cancer with our Kidney Cancer Awareness Quiz.